JAMA Publishes HRT Study JAMA. 2008;299(9):1036-1045. Context: The Women's Health Initiative (WHI) trial of estrogen plus progestin vs placebo was stopped early, after a mean 5.6 years of follow-up, because the overall health risks of hormone therapy exceeded its … [Read more...] about Health Risks and Benefits 3 Years After Stopping Randomized Treatment With Estrogen and Progestin